Clinical trials and medical research services

Assistance with protocol development and sample size
Design of case record forms
Randomization chart
Database design
Data entry
Data checking and quality control
Analysis of data and preparation of report
Assistance with writing manuscript

Co-authored publications in medical journals

Ashby MA, Smith J, Ainslie J, McEwan L. Treatment of nonmelanoma skin cancer at a large Australian center. Cancer 1989;63:1863-71.

McEwan L, Smith J, Matthews J. Late recurrence in localized cutaneous melanoma: its influence on follow-up policy. Plastic and Reconstructive Surgery 1990;86:527-34.

Guiney M, Smith J, Hughes P, Narayan K. Radiation therapy of glottic carcinoma: Peter MacCallum Cancer Institute experience. Australian and New Zealand Journal of Surgery 1992;62:622-7.

Guiney MJ, Smith JG, Hughes P, Yang C, Narayan K. Contemporary management of adult and pediatric brain stem gliomas. International Journal of Radiation Oncology, Biology, Physics 1993;25:235-41.

Bishop J, Smith J, Jeal P, Murray R, Drummond R, Pitt P, Olver I, Bhowal A. The effect of danazol on tumour control and weight loss in patients on tamoxifen with advanced breast cancer: a randomized double-blind placebo controlled trial. European Journal of Cancer 1993;29A:814-8.

Gianoutsos MP, Hunter-Smith D, Smith JG, Hogan D, McEwan L. Oral premedication for local anesthesia in plastic surgery: prospective, randomized, blind comparison of lorazepam and temazepam. Plastic and Reconstructive Surgery 1994;93:901-6.

Basser RL, Smith JG, Worotniuk V, Guiney MJ. Conservative management of squamous cell carcinoma of the anal canal. Australian and New Zealand Journal of Surgery 1994;64:754-8.

Ball D, Bishop J, Smith J, Crennan E, O'Brien P, Davis S, Ryan G, Joseph D, Walker Q. A phase III study of accelerated radiotherapy with and without carboplatin in non-small cell lung cancer: an interim toxicity analysis of the first 100 patients. International Journal of Radiation Oncology, Biology, Physics 1995;31:267-72.

Ryan GF, Ball DL, Smith JG. Treatment of brain metastases from primary lung cancer. International Journal of Radiation Oncology, Biology, Physics 1995;31:273-8.

Phillips KA, Friedlander M, Olver I, Evans B, Smith J, Fitzharris B, McCrystal M, Joughin J, Bishop J. Australasian multicentre phase II study of paclitaxel (Taxol) in relapsed ovarian cancer. Australian and New Zealand Journal of Medicine 1995;25:337-43.

Olver IN, Hughes PG, Smith JG, Narayan K, Bishop JF. Concurrent radiotherapy and continuous ambulatory infusion 5-fluorouracil in advanced head and neck cancer. European Journal of Cancer 1996;32A:249-54.

Millward MJ, Bishop JF, Friedlander M, Levi JA, Goldstein D, Olver IN, Smith JG, Toner GC, Rischin D, Bell DR. Phase II trial of a 3-hour infusion of paclitaxel in previously untreated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology 1996;14:142-8.

Guiney M, Smith J, V Worotniuk. Post-operative radiotherapy for Dukes' B and C rectal cancer: Peter MacCallum Cancer Institute experience. Australasian Radiology 1996;40:326-30.

Matthews KL, Smith JG. Effectiveness of modified Complex Physical Therapy for lymphoedema treatment. Australian Journal of Physiotherapy 1996;42:323-28.

Ball D, Smith J, Bishop J, Olver I, Davis S, O'Brien P, Bernshaw D, Ryan G, Millward M. A phase III study of radiotherapy with and without continuous infusion fluorouracil as palliation for non-small-cell lung cancer. British Journal of Cancer 1997;75:690-7.

Michael M, Bishop JF, Levi JA, Bell DR, Zalcberg JR, Friedlander ML, Olver IN, Smith JG, Toner GC. Australian multicentre phase II trial of paclitaxel in women with metastatic breast cancer and prior chemotherapy. Medical Journal of Australia 1997;166:520-3.

Guiney MJ, Smith JG, Worotniuk V, Ngan S, Blakey D. Radiotherapy treatment for isolated loco-regional recurrence of rectosigmoid cancer following definitive surgery: Peter MacCallum Cancer Institute experience 1981–1990. International Journal of Radiation Oncology Biology Physics 1997;38:1019-25.

McEwan LE, Smith JG. Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses. Australasian Journal of Dermatology 1997;38:187-9.

Corry J, Smith JG, Wirth A, Quong G, Liew KH. Primary central nervous system lymphoma: age and performance status are more important than treatment modality. International Journal of Radiation Oncology Biology Physics 1998;41:615-20.

Wirth A, Smith JG, Ball DL, Corry J, Mameghan H, Bernshaw DLM, Drummond RM. Symptom duration and delay in referral for palliative radiotherapy in cancer patients: a pilot study. Medical Journal of Australia 1998;169:32-6.

Chao MWT, Smith JG, Laidlaw C, Lim Joon D, Ball D. Results of treating primary tumors of the trachea with radiotherapy. International Journal of Radiation Oncology Biology Physics 1998;41:779-85.

Guiney MJ, Smith JG, Worotniuk V, Ngan S. Results of external beam radiotherapy alone for incompletely resected carcinoma of rectosigmoid or rectum: Peter MacCallum Cancer Institute experience 1981–1990. International Journal of Radiation Oncology Biology Physics 1999;43:531-6.

Roos DE, Smith JG. Randomized trials on radioactive iodine ablation of thyroid remnants for thyroid carcinoma – a critique. International Journal of Radiation Oncology Biology Physics 1999;44:493-5.

Bishop JF, Dewar J, Toner GC, Smith J, Tattersall MHN, Olver IN, Ackland S, Kennedy I, Goldstein D, Gurney H, Walpole E, Levi J, Stephenson J, Canetta R, for the Taxol Investigational Trials Group, Australia/New Zealand. Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer. Journal of Clinical Oncology 1999;17:2355-64.

Corry J, Smith JG, Bishop M, Ainslie J. Nodal radiation therapy for metastatic melanoma. International Journal of Radiation Oncology Biology Physics 1999;44:1065-9.

Ball D, Bishop J, Smith J, O'Brien P, Davis S, Ryan G, Olver I, Toner G, Walker Q, Joseph D. A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: final report of an Australian multi-centre trial. Radiotherapy and Oncology 1999;52:129-36.

Roos DE, O'Brien PC, Smith JG, Spry NA, Hoskin PJ, Burmeister BH, Turner SL, Bernshaw DM. A role for radiotherapy in neuropathic bone pain: preliminary response rates from a prospective trial (Trans-Tasman Radiation Oncology Group, TROG 96.05). International Journal of Radiation Oncology Biology Physics 2000;46:975-81.

Rischin D, Boyer M, Smith J, Millward M, Michael M, Bishop J, Zalcberg J, Davison J, Emmett E, McClure B. A phase I trial of docetaxel and gemcitabine in patients with advanced cancer. Annals of Oncology 2000;11:421-6.

Rischin D, Smith J, Millward M, Lewis C, Boyer M, Richardson G, Toner G, Gurney H, McKendrick J. A phase II trial of paclitaxel and epirubicin in advanced breast cancer. British Journal of Cancer 2000;83:438-42.

Corry J, Rischin D, Smith JG, D'Costa IA, Hughes PG, Sexton MA, Sizeland A, Lyons B, Peters LJ. Radiation with concurrent late chemotherapy intensification ("chemoboost") for locally advanced head and neck cancer. Radiotherapy and Oncology 2000;54:123-7.

Dowling AJ, Prince HM, Wirth A, Wolf M, Januscewicz EH, Juneja S, Seymour JF, Gates P, Smith JG. High-dose therapy and autologous transplantation for lymphoma: The Peter MacCallum Cancer Institute experience. Internal Medicine Journal 2001;31:279-89.

Rischin D, Corry J, Smith J, Stewart J, Hughes P, Peters L. Excellent disease control and survival in patients with advanced nasopharyngeal cancer treated with chemoradiation. Journal of Clinical Oncology 2002;20:1845-52.

Jefford M, Toner GC, Smith JG, Ngan SYK, Rischin D, Guiney MJ. Phase II trial of continuous infusion carboplatin, 5-fluorouracil and radiotherapy for localized cancer of the esophagus. American Journal of Clinical Oncology 2002;25:277-82.

Ball D, Smith J, Wirth A, MacManus M. Failure of T stage to predict survival in patients with non-small-cell lung cancer treated by radiotherapy with or without concomitant chemotherapy. International Journal of Radiation Oncology Biology Physics 2002;54:1007-13.

Rischin D, Ackland SP, Smith J, Garg MB, Clarke S, Millward MJ, Toner GC, Zalcberg J. Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics. Annals of Oncology 2002;13:1810-8.

Mileshkin L, Biagi JJ, Mitchell P, Underhill C, Grigg A, Bell R, McKendrick J, Briggs P, Seymour JF, Lillie K, Smith JG, Zeldis JB, Prince HM. Multi-centre phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age. Blood 2003;102:69-77.

Phillips C, Guiney M, Smith JG, Hughes P, Narayan K, Quong G. A randomised trial comparing 35 Gy in 10 fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma. Radiotherapy and Oncology 2003;68:23–6.

Jefford M, Michael M, Rosenthal MA, Davis ID, Green M, McClure B, Smith J, Waite B, Zalcberg J. A novel combination of cisplatin, irinotecan and capecitabine in patients with advanced cancer. Investigational New Drugs 2004;22:185-92.

Schofield P, Ball D, Smith JG, Borland R, O’Brien P, Davis S, Olver I, Ryan G, Joseph D. Optimism and survival in lung carcinoma patients. Cancer 2004;100:1276-82.

Roos DE, Turner SL, O’Brien PC, Smith JG, Spry NA, Burmeister BH, Hoskin PJ, Ball DL. Randomized trial of 8 Gy in 1 versus 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (Trans-Tasman Radiation Oncology Group, TROG 96.05). Radiotherapy and Oncology 2005;75:54-63.

Clinical trials and medical research services

§ Assistance with protocol development and sample size

§ Design of case record forms

§ Randomization chart

§ Database design

§ Data entry

§ Data checking and quality control

§ Analysis of data and preparation of report

§ Assistance with writing manuscript

Typical survival graph

Co-authored publications in medical journals [BUTTON linked to following list as a pdf?]

1. Ashby MA, Smith J, Ainslie J, McEwan L. Treatment of nonmelanoma skin cancer at a large Australian center. Cancer 1989;63:1863-71.

2. McEwan L, Smith J, Matthews J. Late recurrence in localized cutaneous melanoma: its influence on follow-up policy. Plastic and Reconstructive Surgery 1990;86:527-34.

3. Guiney M, Smith J, Hughes P, Narayan K. Radiation therapy of glottic carcinoma: Peter MacCallum Cancer Institute experience. Australian and New Zealand Journal of Surgery 1992;62:622-7.

4. Guiney MJ, Smith JG, Hughes P, Yang C, Narayan K. Contemporary management of adult and pediatric brain stem gliomas. International Journal of Radiation Oncology, Biology, Physics 1993;25:235-41.

5. Bishop J, Smith J, Jeal P, Murray R, Drummond R, Pitt P, Olver I, Bhowal A. The effect of danazol on tumour control and weight loss in patients on tamoxifen with advanced breast cancer: a randomized double-blind placebo controlled trial. European Journal of Cancer 1993;29A:814-8.

6. Gianoutsos MP, Hunter-Smith D, Smith JG, Hogan D, McEwan L. Oral premedication for local anesthesia in plastic surgery: prospective, randomized, blind comparison of lorazepam and temazepam. Plastic and Reconstructive Surgery 1994;93:901-6.

7. Basser RL, Smith JG, Worotniuk V, Guiney MJ. Conservative management of squamous cell carcinoma of the anal canal. Australian and New Zealand Journal of Surgery 1994;64:754-8.

8. Ball D, Bishop J, Smith J, Crennan E, O'Brien P, Davis S, Ryan G, Joseph D, Walker Q. A phase III study of accelerated radiotherapy with and without carboplatin in non-small cell lung cancer: an interim toxicity analysis of the first 100 patients. International Journal of Radiation Oncology, Biology, Physics 1995;31:267-72.

9. Ryan GF, Ball DL, Smith JG. Treatment of brain metastases from primary lung cancer. International Journal of Radiation Oncology, Biology, Physics 1995;31:273-8.

10. Phillips KA, Friedlander M, Olver I, Evans B, Smith J, Fitzharris B, McCrystal M, Joughin J, Bishop J. Australasian multicentre phase II study of paclitaxel (Taxol) in relapsed ovarian cancer. Australian and New Zealand Journal of Medicine 1995;25:337-43.

11. Olver IN, Hughes PG, Smith JG, Narayan K, Bishop JF. Concurrent radiotherapy and continuous ambulatory infusion 5-fluorouracil in advanced head and neck cancer. European Journal of Cancer 1996;32A:249-54.

12. Millward MJ, Bishop JF, Friedlander M, Levi JA, Goldstein D, Olver IN, Smith JG, Toner GC, Rischin D, Bell DR. Phase II trial of a 3-hour infusion of paclitaxel in previously untreated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology 1996;14:142-8.

13. Guiney M, Smith J, V Worotniuk. Post-operative radiotherapy for Dukes' B and C rectal cancer: Peter MacCallum Cancer Institute experience. Australasian Radiology 1996;40:326-30.

14. Matthews KL, Smith JG. Effectiveness of modified Complex Physical Therapy for lymphoedema treatment. Australian Journal of Physiotherapy 1996;42:323-28.

15. Ball D, Smith J, Bishop J, Olver I, Davis S, O'Brien P, Bernshaw D, Ryan G, Millward M. A phase III study of radiotherapy with and without continuous infusion fluorouracil as palliation for non-small-cell lung cancer. British Journal of Cancer 1997;75:690-7.

16. Michael M, Bishop JF, Levi JA, Bell DR, Zalcberg JR, Friedlander ML, Olver IN, Smith JG, Toner GC. Australian multicentre phase II trial of paclitaxel in women with metastatic breast cancer and prior chemotherapy. Medical Journal of Australia 1997;166:520-3.

17. Guiney MJ, Smith JG, Worotniuk V, Ngan S, Blakey D. Radiotherapy treatment for isolated loco-regional recurrence of rectosigmoid cancer following definitive surgery: Peter MacCallum Cancer Institute experience 1981–1990. International Journal of Radiation Oncology Biology Physics 1997;38:1019-25.

18. McEwan LE, Smith JG. Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses. Australasian Journal of Dermatology 1997;38:187-9.

19. Corry J, Smith JG, Wirth A, Quong G, Liew KH. Primary central nervous system lymphoma: age and performance status are more important than treatment modality. International Journal of Radiation Oncology Biology Physics 1998;41:615-20.

20. Wirth A, Smith JG, Ball DL, Corry J, Mameghan H, Bernshaw DLM, Drummond RM. Symptom duration and delay in referral for palliative radiotherapy in cancer patients: a pilot study. Medical Journal of Australia 1998;169:32-6.

21. Chao MWT, Smith JG, Laidlaw C, Lim Joon D, Ball D. Results of treating primary tumors of the trachea with radiotherapy. International Journal of Radiation Oncology Biology Physics 1998;41:779-85.

22. Guiney MJ, Smith JG, Worotniuk V, Ngan S. Results of external beam radiotherapy alone for incompletely resected carcinoma of rectosigmoid or rectum: Peter MacCallum Cancer Institute experience 1981–1990. International Journal of Radiation Oncology Biology Physics 1999;43:531-6.

23. Roos DE, Smith JG. Randomized trials on radioactive iodine ablation of thyroid remnants for thyroid carcinoma – a critique. International Journal of Radiation Oncology Biology Physics 1999;44:493-5.

24. Bishop JF, Dewar J, Toner GC, Smith J, Tattersall MHN, Olver IN, Ackland S, Kennedy I, Goldstein D, Gurney H, Walpole E, Levi J, Stephenson J, Canetta R, for the Taxol Investigational Trials Group, Australia/New Zealand. Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer. Journal of Clinical Oncology 1999;17:2355-64.

25. Corry J, Smith JG, Bishop M, Ainslie J. Nodal radiation therapy for metastatic melanoma. International Journal of Radiation Oncology Biology Physics 1999;44:1065-9.

26. Ball D, Bishop J, Smith J, O'Brien P, Davis S, Ryan G, Olver I, Toner G, Walker Q, Joseph D. A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: final report of an Australian multi-centre trial. Radiotherapy and Oncology 1999;52:129-36.

27. Roos DE, O'Brien PC, Smith JG, Spry NA, Hoskin PJ, Burmeister BH, Turner SL, Bernshaw DM. A role for radiotherapy in neuropathic bone pain: preliminary response rates from a prospective trial (Trans-Tasman Radiation Oncology Group, TROG 96.05). International Journal of Radiation Oncology Biology Physics 2000;46:975-81.

28. Rischin D, Boyer M, Smith J, Millward M, Michael M, Bishop J, Zalcberg J, Davison J, Emmett E, McClure B. A phase I trial of docetaxel and gemcitabine in patients with advanced cancer. Annals of Oncology 2000;11:421-6.

29. Rischin D, Smith J, Millward M, Lewis C, Boyer M, Richardson G, Toner G, Gurney H, McKendrick J. A phase II trial of paclitaxel and epirubicin in advanced breast cancer. British Journal of Cancer 2000;83:438-42.

30. Corry J, Rischin D, Smith JG, D'Costa IA, Hughes PG, Sexton MA, Sizeland A, Lyons B, Peters LJ. Radiation with concurrent late chemotherapy intensification ("chemoboost") for locally advanced head and neck cancer. Radiotherapy and Oncology 2000;54:123-7.

31. Dowling AJ, Prince HM, Wirth A, Wolf M, Januscewicz EH, Juneja S, Seymour JF, Gates P, Smith JG. High-dose therapy and autologous transplantation for lymphoma: The Peter MacCallum Cancer Institute experience. Internal Medicine Journal 2001;31:279-89.

32. Rischin D, Corry J, Smith J, Stewart J, Hughes P, Peters L. Excellent disease control and survival in patients with advanced nasopharyngeal cancer treated with chemoradiation. Journal of Clinical Oncology 2002;20:1845-52.

33. Jefford M, Toner GC, Smith JG, Ngan SYK, Rischin D, Guiney MJ. Phase II trial of continuous infusion carboplatin, 5-fluorouracil and radiotherapy for localized cancer of the esophagus. American Journal of Clinical Oncology 2002;25:277-82.

34. Ball D, Smith J, Wirth A, MacManus M. Failure of T stage to predict survival in patients with non-small-cell lung cancer treated by radiotherapy with or without concomitant chemotherapy. International Journal of Radiation Oncology Biology Physics 2002;54:1007-13.

35. Rischin D, Ackland SP, Smith J, Garg MB, Clarke S, Millward MJ, Toner GC, Zalcberg J. Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibiotics. Annals of Oncology 2002;13:1810-8.

36. Mileshkin L, Biagi JJ, Mitchell P, Underhill C, Grigg A, Bell R, McKendrick J, Briggs P, Seymour JF, Lillie K, Smith JG, Zeldis JB, Prince HM. Multi-centre phase 2 trial of thalidomide in relapsed/refractory multiple myeloma: adverse prognostic impact of advanced age. Blood 2003;102:69-77.

37. Phillips C, Guiney M, Smith JG, Hughes P, Narayan K, Quong G. A randomised trial comparing 35 Gy in 10 fractions with 60 Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma. Radiotherapy and Oncology 2003;68:23–6.

38. Jefford M, Michael M, Rosenthal MA, Davis ID, Green M, McClure B, Smith J, Waite B, Zalcberg J. A novel combination of cisplatin, irinotecan and capecitabine in patients with advanced cancer. Investigational New Drugs 2004;22:185-92.

39. Schofield P, Ball D, Smith JG, Borland R, O’Brien P, Davis S, Olver I, Ryan G, Joseph D. Optimism and survival in lung carcinoma patients. Cancer 2004;100:1276-82.

40. Roos DE, Turner SL, O’Brien PC, Smith JG, Spry NA, Burmeister BH, Hoskin PJ, Ball DL. Randomized trial of 8 Gy in 1 versus 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (Trans-Tasman Radiation Oncology Group, TROG 96.05). Radiotherapy and Oncology 2005;75:54-63.